In six seconds locks € ™ s action of glutamate, the piùà € ™ well-known so-called excitatory amino acids that give off the first phase € ™ s migraine attack. Itâ € ™ vagal stimulator external Gammacore, that at the first signs of a migraine attack is resting on the neck and eliminates the headache in 56% of cases. This andâ € ™ effectiveness was measured by a group of neurologists € ™ s Besta Neurological Institute in Milan led by Licia Grazzi, and colleagues Universitaâ € ™ s € ™ Turin coordinated by Innocenzo Rainero, while almost simultaneously the mechanism by which the stimulator acts andâ € ™ was unveiled by Professor Michael Oshinsky of Thomas Jefferson University.
The study of Licia Grazzi and Innocenzo Rainero andâ € ™ was presented recently to the 66 / mo € ™ s Annual Meeting American Academy of Neurology, held in Philadelphia. The Italian research andâ € ™ was conducted on patients with migraine EtAA € ™ including to 18 and 65 years. With this stimulator, recently also entered in the Register RDM's Ministry of Health, in the space of half an hour the pain andâ € ™ € ™ completely disappeared over the metaâ € ™ of 96 attacks (56%) while nellâ € ™ 11, 5% is andâ € ™ experienced a moderate reduction. The report of Professor Oshinsky, however, published in the journal Pain, has unveiled BECAUSE € ™ € ™ s efficacy as observed by Italian researchers: the electrical micro of Gammacore detain under 6/2 glutamate, the piùà € ™ known excitatory amino acids, cioeâ € ™ neurotransmitters that give off the so-called spreading depression, which andâ € ™ € ™ s the first phase of migraine attack, during which there is progressive and localized reduction € ™ s Activities at € ™ electrical activity of neurons and brain blood circulation . So far, this effect was obtainable with an old drug used nellâ € ™ epilepsy, other disease in which there is an increase of glutamate although to a much greater: valproate, used in adequate dosages allâ € ™ migraine for the first time in 1988 and cluster headaches in 1989. The advantage of the external stimulator andâ € ™ obvious: you get the same result without the side effects that a drug inevitably carries.